Focus on Safety:
PAD™ Technology: A Safe & Effective Process For Optimal Osteoinductivity.
 As you well know, the better the osteoinductive potential in an allograft bio-implant, the greater the potential for bone healing and positive patient outcomes. The key is the safe and consistent management of residual calcium. Studies suggest that restricted calcium in the range of 1% to 4% provides the most osteoinductive product.1-3
While traditional demineralization processes are competent, achieving optimal levels can be hit or miss. In fact, as long as the residual calcium level is below 8%, the industry will allow a product to be designated "demineralized." But thanks to a breakthrough LifeNet Health demineralization technology called PAD™ (Pulsatile Acid Demineralization), it's now possible to achieve residual calcium levels that aren't just acceptable but consistently optimal.
At LifeNet Health, optimal osteoinductivity isn't just a goal—it's the goal. Patented PAD technology maintains strict control of residual calcium by enhancing the way demineralizing acid is applied to the bone. In a series of computer-controlled steps, the vessel containing the bone is rapidly filled (pulsed) with the acid and then drained and neutralized with buffer. This continues until the specific desired residual calcium level is achieved, a targeted range of 1% to 4%.
PAD technology is now used in a range of LifeNet Health products, including Optium DMB®, I/C Graft Chamber®, and cortical chips, cancellous chips, corticocancellous chips and cortical powders.
For more information on these and other LifeNet Health products, contact your local LifeNet Health Bio-Implant Specialist.
1. Herold RW, Pashley DH, Cuening MF: The effects of varying degrees of allograft decalcification on cultured porcine osteoclast cells. J Periodontol. 2002 Feb; 73:213-9
2. Zhang M, Powers RM, and Wolfinbarger L. Effect(s) of the demineralization process on the osteoinductivity of demineralized bone matrix. J Periodontol. 1997; 68:1085-1092
3. Turonis JW, McPherson JC 3rd, Cuening MF. The effects of residual calcium in decalcified freeze-dried bone allograft in a critical-size defect in the Rattus norvegicus calvarium. J Oral Implantol. 2006; 32:55-62
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